Category: Lunch

By Nathan Wei

Tendons are ropes of tissue that connect muscles to bones and allow joint motion. When a muscle contracts, the tendon is pulled and the bone that the tendon is connected to moves.

Tendons consist of collagen (mostly type I collagen) and elastin that sit inside a matrix (framework) with collagen accounting for 65-80% and elastin approximately 1-2% of the mass of the tendon.

Collagen and elastin are produced by special cells called tenoblasts and tenocytes. Crosslinks strengthen the collagen and help them form fibrils which are thin fibers. These fibrils are bunched together to form a collagen fiber which is the basic unit of a tendon. The entire tendon is surrounded by a fine connective tissue sheath called epitenon. The actual structure of a tendon is very complex with fibers being oriented horizontally, longitudinally, and diagonally.

As mentioned above, the basic function of a tendon is to transmit the force created by the muscle to the bone, and, in this way, make joint movement possible. Normally, tendon tissue is extremely tough but it can be damaged through excessive shear forces, trauma, and, recently, with certain drugs.

The Food and Drug Administration recently notified the makers of fluoroquinolone antimicrobial drugs for systemic use of the need to add a boxed warning to the prescribing information about the increased risk of developing tendonitis and tendon rupture. In addition, a Medication Guide for patients was also mandated.

The actual wording of the FDA statement was…

‘Fluoroquinolones are associated with an increased risk of tendinitis and tendon rupture. This risk is further increased in those over age 60, in kidney, heart, and lung transplant recipients, and with use of concomitant steroid therapy. Physicians should advise patients, at the first sign of tendon pain, swelling, or inflammation, to stop taking the fluoroquinolone, to avoid exercise and use of the affected area, and to promptly contact their doctor about changing to a non-fluoroquinolone antimicrobial drug.

Tendinitis and tendon rupture most frequently involves the Achilles tendon, and rupture of the Achilles tendon may require surgical repair. Tendinitis and tendon rupture in the rotator cuff (the shoulder), the hand, the biceps, and the thumb have also been reported. Tendon rupture can occur during or after completion of fluoroquinolone use; cases occurring up to several months after completion of therapy have been reported.

Selection of a fluoroquinolone for the treatment or prevention of an infection should be limited to those conditions that are proven or strongly suspected to be caused by bacteria.’

Currently available fluoroquinolone antimicrobial drugs include ciprofloxacin (marketed as Cipro and generic ciprofloxacin), ciprofloxacin extended release (Cipro XR and Proquin XR), gemifloxacin (marketed as Factive), levofloxacin (marketed as Levaquin), moxifloxacin (marketed as Avelox), norfloxacin (marketed as Noroxin), and ofloxacin (marketed as Floxin and generic ofloxacin).

The warnings about fluoroquinolones and adverse effects on tendons applies only to fluoroquinolones for systemic use (e.g., tablets, capsules and injectable formulations); it does not apply to fluoroquinolones for eye or ear use (e.g., eye drops and ear drops).

This danger has been known to be present for approximately 14 years with case reports first surfacing in the 1990’s.

One group of investigators have stated, ‘current exposure to fluoroquinolones increases the risk of Achilles tendon disorders. This finding is in agreement with a smaller study, in which we found an association between tendinitis and fluoroquinolones’ (van der Linden PD, et al. BMJ 2002;324:1306-1307).

Researchers feel that the mechanism is due to a toxic effect on collagen fibers. This may be caused by a substance called matrix metalloproteinase.

Bottom line? Avoid these antibiotics if you have any of the above risk factors!

About the Author: Nathan Wei, MD FACP FACR is a nationally known board-certified rheumatologist. For more info:

Arthritis Treatment

and

Tendonitis and PRP

Source:

isnare.com

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isnare.com/?aid=292601&ca=Medicines+and+Remedies

Why Choose a Food Franchise Business?

by

Paolo Sobrepe a

The major reason why food cart franchising a very good idea for everyone happens because a more successful company will probably be helping you by using it. Getting a food franchise will not bring you down. Here are some explanations why more people are opting for food franchising as their business. You can use the Internet or contact different companies to be able to learn more about it and the business you are getting into. Another reason why food cart franchising can be easier clients is because you will not be spending a lot of cash just to start earning profits.

If you have a food cart, you ve an income generating machine. All you ve got to do is always to look for someone who is willing to operate on the cart and make money from it. Operation – the amount of hours that you just operate can also be an important factor, but you should consider the different factors before you increase the number of hours you operate. The key to building a passive income with food cart franchise is to ensure that you will be checking everything prior to deciding to hire someone. The reason why food cart franchising has to be successful business model happens because there are thousands of people who are promoting the item.

You have to make sure the cart is going to be able to generate more cash if you were to raise the hours of operation to make sure that you will get more money from your cart. The primary reason why food cart franchising is a great business opportunity is really because you don t have to glance at the guesswork only to be successful from it. An excellent issue which will assist you happen to be expecting the opportunity success of the franchise is that this length of your time the franchisor are in successful operation. The more carts of the brand are visible; the greater brand recognition could be expected from people.

Customers trusts the brand, which franchise businesses already done that to suit your needs, no need for you personally to try this because it will take a long time to earn trust out of your customers. The best part about this method is that you just can have numerous carts as you want, as well as it won t require anything from you, you can simply focus in reading good food cart franchise and build additional money streams. However, there exists a method that you can use which will help you make more cash without spending a lot of cash, and also this is by looking for any food cart franchise. .But additionally you have to remember that there will likely be some companies that are going to take advantage of this excellent success.

Location – this is probably the most crucial thing that you should consider if you want to succeed in food cart franchise. Food is something which we can t live without, and it is one from the largest industries that you can find into in order to have a strong source of greenbacks. But what are the results if you are going to combine MLM and food cart franchising? Do you think it will be a great opportunity for you personally? .There are lots of food cart franchising companies that you simply can contact if you wish to start earning profits with ecommerce.

Paolo Sobrepe a – graduated Business Admin, an entrepreneur.

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Article Source:

ArticleRich.com